A Study of Efficacy and Tolerability of Rosehip Extract (Gopo) vs. Ibuprofen (a nsaid) in Treatment of Osteoarthritis in Weight Bearing Joints

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Published Jul 11, 2019
https://doi.org/10.18311/ijmds/2019/23417
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Volume 8, Issue 2, July 2019

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Hina Lal
Junior Resident, Department of Pharmacology, GMC, Patiala – 147001, Punjab
Harinder Singh
Ex Professor, Department of Pharmacology, GMC, Patiala – 147001, Punjab
Kawarjit Singh Sandhu
Associate Professor, Department of Orthopaedics, GMC, Patiala – 147001, Punjab
Vijay K. Sehgal
Professor and Head, Department of Pharmacology, GMC, Patiala – 147001, Punjab

Abstract

Introduction: Osteoarthritis is the most common form of arthritis. Osteoarthritis is a joint failure, which occurs due to pathological change in all structure joint. Aim: The aim of the study was to compare the efficacy and tolerability of Rosehip Extract and ibuprofen along with individual effect of both drugs. Materials and Methods: This was an open, randomized, prospective study to compare ROSE HIP Extract and IBUPROFEN for treatment of Osteoarthritis in 100 patients. In this study two comparative groups (50 each) were taken. First group was prescribed 400 mg TDS Ibuprofen and the other group was given Rose hip extract in the form of 275 mg capsule BD. The pain assessment was done through Womac scale and visual analogue scale. The data was collected for efficacy and tolerability for both drugs at 14 days and 3 months. Result: In ibuprofen group, the mean score of pain intensity on womac scale on visit 1 was 39.2 ± 9.58 which was decreased to 11.62 ± 4.97 in the last visit. On VAS scale on visit 1 was 7.26 ± 1.426 and was decreased to 3.36 ± 1.467 at visit 3. In rosehip group. The mean score of pain intensity on WOMAC scale on visit 1 was 38.44 ± 8.45, 30.88 ± 8.068 which was decreased to 26.68 ± 8.474. The mean score of pain intensity at on VAS scale on visit 1 was 7.02 ± 1.06, 5.84 ± 1 and was decreased to 4.6 ± 1.16 at the end of study. Conclusion: Ibuprofen is a better choice than rosehip because it had shown better improvement. Both rosehip and ibuprofen were well tolerated.

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How to Cite
Lal, H., Singh, H., Sandhu, K. S., & Sehgal, V. K. (2019). A Study of Efficacy and Tolerability of Rosehip Extract (Gopo) vs. Ibuprofen (a nsaid) in Treatment of Osteoarthritis in Weight Bearing Joints. International Journal of Medical and Dental Sciences, 1754–1758. https://doi.org/10.18311/ijmds/2019/23417
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